Adjusted cut-off point of mean corpuscular volume for screening for iron deficiency anemia among HIV infected patients receiving highly active antiretroviral therapy

Rujittika Mungmunpuntipantip, Viroj Wiwanitkit

Abstract


Human immunodeficiency virus (HIV) infection an important virus infection that can directly affects lymphocyte and results in impaired immune status. The HIV infection is still endemic worldwide at present. There is a chance of concurrence between HIV infection and other medical problems. The nutritional problem is a basic public health problem seen worldwide. Iron deficiency anemia is an important nutritional disorder that can affect a person in any sex and age group. The diagnosis of iron deficiency anemia is usually based on iron study. However, due to the complex investigation, the screening by automated hematology analyzer is generally done. A microcytic red blood cell result from automated hematological screening is the basic clue for further diagnosis. In the area where anemic disorder is common such as Indochina, the MCV screening is generally done. However, there are several possible causes of anemia in that area including iron deficiency and hemoglobin disorder. The application of MCV cut-off is generally used for diagnosis. An important consideration in using the cut-off point is the interference effect from other pathophysiological condition. In HIV infected patient, the patient usually receives antiretroviral therapy and it is noted that the antiretroviral drug can result in alteration of MCV parameter. In this article, the authors assess the change of MCV parameter due to antiretroviral drug among HIV infected patient. A mathematical model study is done to find the new adjusted cut-off point of mean corpuscular volume for screening for iron deficiency anemia among HIV infected patients receiving highly active antiretroviral therapy.

 

Core tip:Human immunodeficiency virus (HIV) infection is an important
virus infection that can directly affect lymphocyte and results in
impaired immune status.

 

Citation: Mungmunpuntipantip R, Wiwanitkit V. Adjusted cut-off point of mean corpuscular volume for screening for iron deficiency anemia among HIV infected patients receiving highly active antiretroviral therapy. Angiologica Persica Acta. 2019;4:e02.


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